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Moderna completes enrolment of phase 2 study of its mRNA vaccine against Covid-19

mRNA-1273 is Moderna’s second mRNA vaccine for an infectious disease to complete enrollment of a Phase 2 study, following the Company’s CMV Phase 2 study, which was fully

The post Moderna completes enrolment of phase 2 study of its mRNA vaccine against Covid-19 appeared first on Pharmaceutical Business review.


Concert receives FDA breakthrough status for CTP-543 in alopecia areata

There are currently no drugs approved by the FDA for the treatment of alopecia areata, an autoimmune disorder in which the immune system attacks hair follicles, resulting in

The post Concert receives FDA breakthrough status for CTP-543 in alopecia areata appeared first on Pharmaceutical Business review.


AstraZeneca, Merck secure EU nod for Lynparza to treat germline BRCA-mutated metastatic pancreatic cancer

The EC approval allows using Lynparza as a maintenance treatment for adult patients with germline BRCA1/2 mutations who have metastatic adenocarcinoma of the pancreas and have not progressed

The post AstraZeneca, Merck secure EU nod for Lynparza to treat germline BRCA-mutated metastatic pancreatic cancer appeared first on Pharmaceutical Business review.


Vor Biopharma closes $110m Series B financing

Proceeds will advance the company’s lead candidate VOR33 into clinical trials, deepen its portfolio, and accelerate the validation of additional targets for its scientific platform, which is designed

The post Vor Biopharma closes $110m Series B financing appeared first on Pharmaceutical Business review.


Ridgeback begins enrolment for phase 2 Covid-19 trial of EIDD-2801

The trial of EIDD-2801 will be held using a newly launched Covid-19 drug testing platform called AGILE, which has been developed in the UK by the University of

The post Ridgeback begins enrolment for phase 2 Covid-19 trial of EIDD-2801 appeared first on Pharmaceutical Business review.


FDA grants orphan drug designation to Neurogene’s gene therapy for treatment of CLN5 Batten disease

Batten disease, a common name for a rare class of diseases called neuronal ceroid lipofuscinoses (NCL), affects an estimated 2-4 out of every 100,000 children in the United

The post FDA grants orphan drug designation to Neurogene’s gene therapy for treatment of CLN5 Batten disease appeared first on Pharmaceutical Business review.


Corvus begins phase 1 Covid-19 clinical trial with novel immunotherapy

The company is evaluating an agonistic (immunostimulatory) humanised monoclonal antibody, dubbed CPI-006, which is said to show a potential new approach to immunotherapy of infectious diseases and cancer.

The post Corvus begins phase 1 Covid-19 clinical trial with novel immunotherapy appeared first on Pharmaceutical Business review.


VROBIO announces new patients dosed in Gaucher disease and cystinosis trials

The company also announced that the second patient has been dosed in the ongoing investigator-sponsored Phase 1/2 clinical trial of AVR-RD-04 for cystinosis. “The first patient dosed is an important

The post VROBIO announces new patients dosed in Gaucher disease and cystinosis trials appeared first on Pharmaceutical Business review.


Sunovion’s SEP-4199 fails to meet primary endpoint in SEP380-201 trial

The primary endpoint of the SEP380-201 trial was the variation from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score after six weeks of treatment with SEP-4199. According

The post Sunovion’s SEP-4199 fails to meet primary endpoint in SEP380-201 trial appeared first on Pharmaceutical Business review.


Sinovac Covid-19 vaccine collaboration with Butantan receives approval from Brazilian regulator for phase III trial

On July 3, 2020, the Brazilian National Regulatory Agency, Anvisa, granted approval to a phase III clinical trial sponsored by Instituto Butantan to test efficacy and safety of

The post Sinovac Covid-19 vaccine collaboration with Butantan receives approval from Brazilian regulator for phase III trial appeared first on Pharmaceutical Business review.


Drugs.com - News for Health Professionals
Headline news from Drugs.com. Comprehensive and up-to-date drug news for both consumers and healthcare professionals.

Odds of Surgery Lower for Black Patients With Esophageal Cancer
THURSDAY, July 9, 2020 -- Black patients with esophageal cancer have a reduced likelihood of receiving surgery, and patients not undergoing surgery have higher mortality, according to a study published online June 4 in the Journal of...
Physically Demanding Jobs May Raise Risk for Knee Osteoarthritis
THURSDAY, July 9, 2020 -- The odds of knee osteoarthritis (OA) are increased in association with heavy physically demanding occupations and occupational activities, according to a review published online July 7 in Arthritis Care & Research. Xia...
Newborn Iodine Status Not Tied to Congenital Hypothyroidism
THURSDAY, July 9, 2020 -- Blood iodine concentrations in newborns do not vary for infants with or without congenital hypothyroidism (CH), although they are higher in cases versus controls in the neonatal intensive care unit (NICU), according to a...
Serum Neurofilament Light May Help Assess Concussion, TBI
THURSDAY, July 9, 2020 -- Serum neurofilament light (NfL) may be a biomarker for acute and repetitive sports-related concussion and traumatic brain injury (TBI), according to a study published online July 8 in Neurology. For the study, Pashtun...
Spectrum of Neurological Disorders Linked to SARS-CoV-2
THURSDAY, July 9, 2020 -- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a spectrum of neurological disorders, according to a study published online July 8 in Brain. Ross W. Paterson, Ph.D., from the...
Higher Vitamin C, Carotenoid Intake May Lower Risk for T2DM
THURSDAY, July 9, 2020 -- Higher intakes of vitamin C and carotenoids, as well as total whole grains, are associated with a lower risk for type 2 diabetes, according to two studies published online July 8 in The BMJ. Ju-Sheng Zheng, Ph.D., from the...
Multifactor Program Does Not Cut Serious Fall Injuries in Elderly
THURSDAY, July 9, 2020 -- A nurse-administered multifactorial intervention does not result in a significantly lower rate of first adjudicated serious fall injury among older adults at increased risk for fall injuries, according to a study published...
CDC Updates Info on COVID-19 Cases at Meat, Poultry Processing Facilities
THURSDAY, July 9, 2020 -- COVID-19 was confirmed in 16,233 workers in 239 meat and poultry processing facilities in 23 states through May 31, 2020, according to research published in the July 7 early-release issue of the U.S. Centers for Disease...
Half of Individuals With MI at Age 50 or Younger Are Smokers
THURSDAY, July 9, 2020 -- About half of individuals who experience a myocardial infarction at 50 years or younger are smokers, and among these individuals, smoking cessation is associated with a reduced risk for all-cause and cardiovascular...
2008 to 2018 Saw Increase in Shingles Vaccination in Over 60s
THURSDAY, July 9, 2020 -- From 2008 to 2018, there was an increase in shingles vaccination among adults aged 60 years and older, with demographic, socioeconomic, and geographic variations in vaccination rates, according to a July data brief...
11 Dengue Fever Cases Confirmed in Florida Keys
WEDNESDAY, July 8, 2020 -- Confirmation of an 11th case of dengue fever in the Florida Keys was announced Tuesday by state health officials. The officials said all 11 cases of the mosquito-borne disease have been in Key Largo, including eight cases...
Employers Can Refuse to Provide Birth Control Coverage: U.S Supreme Court
WEDNESDAY, July 8, 2020 -- More than 70,000 U.S. women could be left without cost-free birth control after the Supreme Court upheld a Trump administration policy change that permits some employers to refuse to provide contraceptive coverage on...
U.S. Launches Suicide Prevention Campaign
WEDNESDAY, July 8, 2020 -- A national campaign to prevent suicide has been launched by the U.S. government. The REACH campaign urges people to reach out to others, especially during the COVID-19 pandemic, and to acknowledge daily stress in people's...
Upadacitinib Beats Methotrexate in Early Rheumatoid Arthritis
WEDNESDAY, July 8, 2020 -- Upadacitinib monotherapy results in improved outcomes versus methotrexate for patients with predominantly early rheumatoid arthritis, according to a study published online July 8 in Arthritis & Rheumatology. Ronald...
Multisystem Inflammatory Syndrome in Children Profiled
WEDNESDAY, July 8, 2020 -- Multisystem inflammatory syndrome in children (MIS-C), which coincided with COVID-19, is described in children and adolescents in the United States and New York state in two reports published online June 29 in the New...
Interruption of Sitting May Cut Acute Postprandial Response
WEDNESDAY, July 8, 2020 -- When individuals interrupt prolonged sitting with bouts of light physical activity, postprandial insulin and glucose levels are reduced, according to a study published in the June issue of Medicine & Science in Sports...
American Cancer Society Updates HPV Vaccination Guidelines
WEDNESDAY, July 8, 2020 -- The American Cancer Society has updated guidelines on human papillomavirus (HPV) vaccination, emphasizing that vaccination should be routinely offered at age 9 to 12 years; the updated recommendations were published online...
Rising Number of People Report Anxiety, Depression During COVID-19
WEDNESDAY, July 8, 2020 -- New evidence shows that depression and anxiety are increasing as a result of the COVID-19 pandemic, according to the results of a survey released by Mental Health America (MHA). MHA has had an online screening program...
Huntington Disease Brain Changes ID'd 24 Years Before Symptoms
WEDNESDAY, July 8, 2020 -- The earliest brain changes due to Huntington disease (HD) can be detected in cerebrospinal fluid (CSF) 24 years before clinical symptoms show, according to a study published in the June 1 issue of The Lancet...
February to March 2020 Saw Surge in Hydroxychloroquine Rx
WEDNESDAY, July 8, 2020 -- From February to March 2020, there was a considerable increase in the number of patients receiving outpatient prescriptions for hydroxychloroquine, chloroquine, and azithromycin, according to a research letter published...
Long-Acting Drug Targeting Capsid Protein Promising for HIV
WEDNESDAY, July 8, 2020 -- A small molecule that disrupts the functions of the HIV capsid protein, GS-6207, demonstrates a reduction in plasma viral load and shows sustained plasma exposure, according to a study published online July 1 in...
Statin Use May Cut All-Cause, CVD Mortality in Those 75 and Older
WEDNESDAY, July 8, 2020 -- In U.S. veterans aged 75 years and older, statin use is associated with reduced all-cause and cardiovascular mortality, according to a study published in the July 7 issue of the Journal of the American Medical...
2010 Healthy, Hunger-Free Kids Act Tied to Drop in Childhood Obesity
WEDNESDAY, July 8, 2020 -- Implementation of the 2010 Healthy, Hunger-Free Kids Act significantly cut childhood obesity among children living in poverty, according to a study published in the July issue of Health Affairs. Erica L. Kenney, Sc.D.,...
Dairy Does Not Protect Against Bone Loss During Menopause Transition
WEDNESDAY, July 8, 2020 -- Dairy intake is not associated with improvements in bone mineral density or risk for fractures in women transitioning to menopause, according to a study recently published in Menopause. Taylor C. Wallace, Ph.D., from...
Efforts to Reduce New HIV Infections in Children Faltering
TUESDAY, July 7, 2020 -- Efforts to reduce new HIV infections in children worldwide are faltering, according to a new report on progress toward Start Free, Stay Free, AIDS Free targets. Countries agreed to a range of HIV prevention and treatment...
Suspected Plague Case Reported in China
TUESDAY, July 7, 2020 -- A suspected bubonic plague case in the Bayannur district of the Inner Mongolia Autonomous Region of China has been reported by local officials. Residents were told not to hunt wild animals such as marmots and that anyone...
COVID-19 Antibody Cocktail Begins Late-Stage Human Trials
TUESDAY, July 7, 2020 -- Late-stage human trials to assess whether a double antibody cocktail can prevent and treat COVID-19 infection have started, biotechnology company Regeneron said Monday. A phase 3 trial of REGN-COV2 will assess whether it...
Company Gets $1.6 Billion From U.S. Government for COVID-19 Vaccine
TUESDAY, July 7, 2020 -- Vaccine maker Novavax will receive $1.6 billion from the U.S. government to provide 100 million doses of a COVID-19 vaccine by early 2021, the Maryland-based company said Monday. This is the largest deal announced by the...
Complementary, Alternative Medicine Use Increasing for MS
TUESDAY, July 7, 2020 -- For people with multiple sclerosis (pwMS), there has been an increase in use of complementary and alternative medicine (CAM), according to a study published in the June issue of Multiple Sclerosis and Related...
Acute Ischemic Stroke Risk Higher With COVID-19 Than Influenza
TUESDAY, July 7, 2020 -- Patients with COVID-19 appear to have a heightened risk for acute ischemic stroke compared with patients with influenza, according to a study published online July 2 in JAMA Neurology. Alexander E. Merkler, M.D., from Weill...
Excessive Sugar Tied to Fat Deposits Around Heart, Other Organs
TUESDAY, July 7, 2020 -- Long-term intake of added sugar and sugar-sweetened beverages is associated with higher pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes, according to a study published online June...
Social Distancing Effective for Mitigating COVID-19 Spread
TUESDAY, July 7, 2020 -- Social distancing is one of the main measures to combat COVID-19 spread, according to a study published online July 1 in The Lancet Infectious Diseases. Hamada S. Badr, Ph.D., from Johns Hopkins University in Baltimore, and...
Review: Pre/Probiotics May Be Useful for Depression, Anxiety
TUESDAY, July 7, 2020 -- Pre/probiotic therapy may be useful for patients with depression and/or anxiety disorders, according to a review published online July 6 in BMJ Nutrition, Prevention & Health. Sanjay Noonan, from Brighton and Sussex...
USPSTF Advises Annual Low-Dose CT Lung Screening for High-Risk Individuals
TUESDAY, July 7, 2020 -- The U.S. Preventive Services Task Force (USPSTF) recommends annual low-dose computed tomography (LDCT) screening for people aged 50 to 80 years at high lung cancer risk due to smoking history. These recommendations form the...
Chilblains in Recent Case Series Not Tied to COVID-19 Infection
TUESDAY, July 7, 2020 -- In a case series of 31 patients, published online June 25 in JAMA Dermatology, chilblains did not appear to be directly associated with COVID-19. Anne Herman, M.D., from the Université Catholique de Louvain in...
Early Breast Cancer Screening Benefits Childhood Cancer Survivors
TUESDAY, July 7, 2020 -- For childhood cancer survivors, early initiation of breast cancer screening with magnetic resonance imaging (MRI) may reduce breast cancer mortality by more than half, according to a study published online July 7 in the...
Genetic Variant Identified for Adult-Onset Hearing Loss
TUESDAY, July 7, 2020 -- An inherited form of adult-onset hearing loss is relatively common, according to a study published online July 6 in the Journal of Medical Genetics. Suzanne E. de Bruijn, from the Radboud University Medical Center in...
Oral Corticosteroid Bursts Carry Risk for Severe Adverse Events
TUESDAY, July 7, 2020 -- Prescriptions for oral steroid bursts are associated with a 1.8- to 2.4-fold increased risk for severe adverse events within the first month after initiation of drug therapy, according to a study published online July 7 in...
Outcomes Similar for COVID-19 in Patients With, Without HIV
MONDAY, July 6, 2020 -- Persons with HIV (PWH) hospitalized with COVID-19 have similar outcomes to demographically-matched patients without HIV, according to a study published online June 28 in Clinical Infectious Diseases. Keith Sigel, M.D.,...
Incidence of Abusive Head Trauma in Infants May Be Up During Lockdown
MONDAY, July 6, 2020 -- From March 23 to April 23, 2020, there was a very large increase in the incidence of abusive head trauma (AHT) seen in very young children, according to a research letter published online July 2 in the Archives of Disease in...

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