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Pharmaceutical Business review

Cyclica launches new multi-targeted drug design technology Ligand Design

This revolutionary platform empowers scientists in the pharmaceutical industry to generate novel drug-like compounds by combining powerful methods for molecule generation, ADMET prediction, and high-throughput ligand-protein interaction prediction.

The post Cyclica launches new multi-targeted drug design technology Ligand Design appeared first on Pharmaceutical Business review.


FDA approves SORILUX for adolescent plaque psoriasis

SORILUX is now approved for treating plaque psoriasis of the scalp and body in patients aged 12 years and older. The FDA approved SORILUX in 2010 based on

The post FDA approves SORILUX for adolescent plaque psoriasis appeared first on Pharmaceutical Business review.


Amgen to acquire Danish firm Nuevolution for £132m

Based in Copenhagen, Nuevolution shares its advanced discovery platform and programmes with pharmaceutical and biotechnology companies to develop novel medical treatment options for the patients. Amgen’s offer represents

The post Amgen to acquire Danish firm Nuevolution for £132m appeared first on Pharmaceutical Business review.


WuXi Biologics signed letter of intent for long-term vaccine manufacturing contract

WuXi Vaccines is a joint venture company to be established between WuXi Biologics and Shanghai based Hile Bio-Technology (stock code 603718.SH). The business model of WuXi Vaccines is

The post WuXi Biologics signed letter of intent for long-term vaccine manufacturing contract appeared first on Pharmaceutical Business review.


Merck to buy Peloton Therapeutics in £1.72bn deal

Under the deal, Merck’s subsidiary will purchase all outstanding shares of Peloton in exchange for an upfront payment of $1.05bn (£825m) in cash. The shareholders of Peloton will

The post Merck to buy Peloton Therapeutics in £1.72bn deal appeared first on Pharmaceutical Business review.


Lilly’s Mirikizumab succeeds in phase 2 study in Crohn’s disease

Patients treated with mirikizumab in the SERENITY Phase 2 study achieved significant reductions in clinical and endoscopic measures of disease activity at 12 weeks compared to placebo. The

The post Lilly’s Mirikizumab succeeds in phase 2 study in Crohn’s disease appeared first on Pharmaceutical Business review.


SpringWorks Therapeutics initiates phase 3 trial of Nirogacestat in desmoid tumors

Desmoid tumors are rare and often debilitating and disfiguring soft-tissue tumors that can aggressively invade surrounding healthy tissues, including joints, muscles, blood vessels, nerves and internal organs. Depending

The post SpringWorks Therapeutics initiates phase 3 trial of Nirogacestat in desmoid tumors appeared first on Pharmaceutical Business review.


Catalent wraps up $1.2bn acquisition of gene therapy CDMO Paragon

The all-cash deal between Catalent and Paragon, which was signed in April 2019, was completed after meeting of customary closing conditions such as the expiration of the waiting

The post Catalent wraps up $1.2bn acquisition of gene therapy CDMO Paragon appeared first on Pharmaceutical Business review.


AstraZeneca says Symbicort as anti-inflammatory reliever reduces attacks in mild asthma

These results are published in the New England Journal of Medicine and are being presented at the American Thoracic Society 2019 International Conference. The trial compared Symbicort Turbuhaler with

The post AstraZeneca says Symbicort as anti-inflammatory reliever reduces attacks in mild asthma appeared first on Pharmaceutical Business review.


US FDA approves GATTEX for children with short bowel syndrome

In children, SBS is a life-threatening, chronic, and rare malabsorption disorder resulting from surgical removal of a large portion of the intestine, which is typically due to congenital

The post US FDA approves GATTEX for children with short bowel syndrome appeared first on Pharmaceutical Business review.


Drugs.com - News for Health Professionals
Headline news from Drugs.com. Comprehensive and up-to-date drug news for both consumers and healthcare professionals.

Firearms Leading Cause of Death Among Young Adult Men
THURSDAY, May 23, 2019 -- Firearm mortality in the United States, Mexico, Brazil, and Colombia is highest among young adult men, and is strongly associated with race, ethnicity, and low education levels, according to a study published online May 21...
Decrease in PM2.5-Related U.S. Mortality From 2010 to 2017
THURSDAY, May 23, 2019 -- From 2010 to 2017, there was a decrease in annual excess mortality related to fine particulate matter (PM2.5), while ozone (O3)-related mortality remained stable in the United States, according to a study published online...
High-Deductible Health Plans May Be Harmful for Patients With COPD
THURSDAY, May 23, 2019 -- For patients with chronic obstructive pulmonary disease (COPD), high-deductible health plans (HDHPs) are associated with increased likelihood of reporting foregoing care because of costs and cost-related nonadherence,...
Blood Donor Screening Data IDs Familial Hypercholesterolemia
THURSDAY, May 23, 2019 -- Data from a blood donor screening program could represent a novel strategy for identifying familial hypercholesterolemia (FH), according to a study published online May 22 in JAMA Cardiology. Candace L. Jackson, M.D.,...
Pediatricians Should Encourage Fish Consumption for Children
THURSDAY, May 23, 2019 -- Fish and shellfish consumption should be encouraged for children, according to a technical report published online May 20 in Pediatrics. Aaron S. Bernstein, M.D., M.P.H., from Boston Children's Hospital and Harvard Medical...
Severe Maternal Complication Risk Four Times Higher With Twins
THURSDAY, May 23, 2019 -- Women with twin pregnancies have a four-fold increased risk for severe maternal complications both before and after delivery, compared to women with singleton pregnancies, according to a study published online May 9 in...
Early cART Leads to Enhanced T Cell Function in HIV Infection
THURSDAY, May 23, 2019 -- Early combination antiretroviral therapy (cART) leads to persistent functional T cell responses in most individuals with hyperacute HIV-1 infection, according to a study published online May 22 in Science Translational...
Classification System Developed for Cardiogenic Shock
THURSDAY, May 23, 2019 -- A classification system has been developed for categorizing cardiogenic shock; the consensus statement, endorsed by the American College of Cardiology, American Heart Association, Society of Critical Care Medicine, and...
Most At-Risk Opt Out of Genetic Testing for Huntington Disease
THURSDAY, May 23, 2019 -- The vast majority of people at risk for Huntington disease (HD) choose not to be tested preemptively, mainly because there is no cure for the disease, according to a study published online May 15 in Clinical Genetics. Karen...
Medication Nonadherence Common in Patients With T2DM
THURSDAY, May 23, 2019 -- Routine urine samples can be used to test for medication adherence in patients with type 2 diabetes, according to a study published in the June issue of Diabetes Care. Prashanth Patel, M.B.B.S., from the University...
CDC: Seniors Use Various Strategies to Reduce Rx Costs
WEDNESDAY, May 22, 2019 -- A proportion of older adults employ strategies to reduce prescription drug costs, according to a May data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics. Robin...
Half-Price Version of Humalog Insulin Now Available
WEDNESDAY, May 22, 2019 -- A half-price version of Humalog insulin is now available in the United States, Eli Lilly said Wednesday. The company's generic version of its Humalog U-100 is being sold under the chemical name insulin lispro, the...
Suboptimal Diet Accounted for >80,000 Cancer Cases in 2015
WEDNESDAY, May 22, 2019 -- In 2015, more than 80,000 cancer cases were associated with suboptimal diet in U.S. adults, according to a study published online May 22 in JNCI: Cancer Spectrum. Fang Fang Zhang, M.D., Ph.D., from the Friedman School of...
CDC: Cancer Death Rates Decreased, Heart Disease Deaths Rose
WEDNESDAY, May 22, 2019 -- Cancer death rates declined for adults aged 45 to 64 years from 1999 to 2017, while heart disease death rates decreased to 2011 and then increased, according to the May 22 National Vital Statistics Reports, a publication...
Women With COPD Have Worse QoL, Increased Symptom Burden
WEDNESDAY, May 22, 2019 -- Compared with men, women with chronic obstructive pulmonary disease (COPD) have reduced respiratory-specific and general quality of life (QoL) and are more likely to be symptomatic, according to a study presented at the...
Closed ICU Model May Reduce Hospital-Acquired Infections
WEDNESDAY, May 22, 2019 -- A closed intensive care unit (ICU) model, whereby a patient is evaluated and admitted under an intensivist and orders involving patient care are written by the ICU team, is associated with a reduction in certain types of...
Incidence of Parkinson Disease Increased in Bipolar Disorder
WEDNESDAY, May 22, 2019 -- Patients with bipolar disorder (BD) have an increased incidence of Parkinson disease (PD), according to a study published online May 22 in Neurology. Mao-Hsuan Huang, M.D., from Taipei Veterans General Hospital in Taiwan,...
Bystander Resuscitation Attempted Less Often for Women in Cardiac Arrest
WEDNESDAY, May 22, 2019 -- In out-of-hospital cardiac arrest (OHCA), women are less often resuscitated than men, and they have lower survival rates with resuscitation, according to a study published online May 21 in the European Heart...
Some Women With HIV Struggling to Achieve Viral Suppression
WEDNESDAY, May 22, 2019 -- A considerable proportion of women with HIV have a high probability of viremia above 200 copies/mL, according to a study published online May 17 in JAMA Network Open. Seble G. Kassaye, M.D., from the Georgetown University...
Weight Loss Tied to Adverse Outcomes in Deceased Donor Kidney Transplant
WEDNESDAY, May 22, 2019 -- Substantial weight loss before deceased donor kidney transplantation (DDKT) is associated with worse outcomes among DDKT recipients, according to a study published online May 21 in the American Journal of Kidney...
Treatment Rates Low for Parents With Opioid Use Disorder
WEDNESDAY, May 22, 2019 -- Rates of treatment are low for parents with opioid use disorder (OUD) or other substance use disorders (SUDs), according to a study published in the May/June issue of the Annals of Family Medicine. Lisa Clemans-Cope,...
Adverse Liver Outcomes Up With Diagnosis of NAFLD/NASH
WEDNESDAY, May 22, 2019 -- The risks for cirrhosis and hepatocellular carcinoma (HCC) are increased for patients with a recorded diagnosis of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), according to a study...
Targeted Laser Surgery Treats Temporal Lobe Epilepsy
WEDNESDAY, May 22, 2019 -- Laser interstitial thermal therapy (LITT) targeting greater amygdala volume is more likely to be associated with Engel I outcomes for mesial temporal lobe epilepsy (mTLE), according to a study published online May 21 in...
Depression, PTSD Linked to More Participation in Cardiac Rehab
WEDNESDAY, May 22, 2019 -- The presence of comorbid depression and/or posttraumatic stress disorder (PTSD) is associated with increased participation in cardiac rehabilitation (CR) among patients with ischemic heart disease, according to a study...
Vitamin D Deficiency Tied to Gestational Diabetes Risk
WEDNESDAY, May 22, 2019 -- Maternal vitamin D deficiency, as early as the first trimester of pregnancy, is associated with an increased risk for gestational diabetes mellitus (GDM), according to a study recently published in Diabetes, Obesity and...
Poor Broadband Penetration in Rural Areas Limits Telemedicine
TUESDAY, May 21, 2019 -- Broadband penetration rates are considerably lower in the most rural counties, especially where access to primary care physicians and psychiatrists is inadequate, according to a study published online May 21 in the Annals of...
Bill Would Raise U.S. Legal Age to Buy Tobacco to 21
TUESDAY, May 21, 2019 -- A bill to raise the minimum age for buying any type of tobacco product, including electronic cigarettes, from 18 to 21 years was introduced Monday by Senate Majority Leader Mitch McConnell. The proposed bipartisan...
Homemade Sunscreen Recipes Commonly Shared, Offer Low Protection
TUESDAY, May 21, 2019 -- There is widespread public interest in and acceptance of homemade sunscreens, even though they often do not offer sufficient protection from ultraviolet radiation, according to a study published online May 20 in Health...
Favorable Trends Seen in Lipids, Apolipoprotein B in U.S. Youth
TUESDAY, May 21, 2019 -- Between 1999 and 2016, there were favorable trends in lipid and apolipoprotein B levels in U.S. youth, according to a study published in the May 21 issue of the Journal of the American Medical Association. Amanda M. Perak,...
Four Clinical Phenotypes Identified for Sepsis
TUESDAY, May 21, 2019 -- Four distinct clinical phenotypes have been identified among patients with sepsis, according to a study published online May 19 in the Journal of the American Medical Association to coincide with the American Thoracic...
Higher Consumption of Sugary Drinks May Up Mortality in Adults
TUESDAY, May 21, 2019 -- Consumption of sugary beverages, including 100 percent fruit juices, is associated with higher all-cause mortality in U.S. adults, according to a study published online May 17 in JAMA Network Open. Lindsay J. Collin, M.P.H.,...
Regular Puzzle Use May Improve Cognition in Older Adults
TUESDAY, May 21, 2019 -- Older adults who regularly perform word and number puzzles have higher cognitive functioning than those who do not engage in such activities, according to two studies recently published in the International Journal of...
Gender Gap in U.S. Youth Suicide Narrowed From 1975 to 2016
TUESDAY, May 21, 2019 -- There was a significant reduction in the gap between male and female rates of suicide among youth aged 10 to 19 years in the United States from 1975 through 2016, according to a study published online May 17 in JAMA Network...
Clinical Drug Diversion Costly to Health Care Organizations
TUESDAY, May 21, 2019 -- U.S. health care organizations lost nearly $454 million due to clinical drug diversion in 2018, according to the 2019 Drug Diversion Digest, released by Protenus Inc. The health care compliance analytics firm Protenus...
Octogenarians With Acute Myeloid Leukemia Have Poor Survival
TUESDAY, May 21, 2019 -- Octogenarians with acute myeloid leukemia (AML) have a one-month mortality rate of 41 percent and overall survival (OS) of 1.5 months, according to a research letter published in the June issue of the American Journal of...
Fracture Risk Tool Useful for Women on Aromatase Inhibitors
TUESDAY, May 21, 2019 -- The FRAX fracture risk tool can stratify fracture risk equally well among women receiving aromatase inhibitor (AI) therapy for breast cancer and nonusers of AI therapy, according to a study published online May 9 in the...
Non-Rx Fentanyl Up in Urine Tests Positive for Other Drugs
TUESDAY, May 21, 2019 -- An increasing number of urine drug test (UDT) results positive for cocaine or methamphetamine are also positive for nonprescribed fentanyl, according to a study recently published in JAMA Network Open. Leah LaRue, Pharm.D.,...
Rates of Depression Up in U.S. Women at Hospital to Give Birth
TUESDAY, May 21, 2019 -- From 2000 to 2015, the rates of depressive disorders recorded for women during delivery hospitalization increased nationally, according to a study published online May 9 in Obstetrics & Gynecology. Sarah C. Haight,...
Weight Gain, Loss in Seniors May Increase Risk for Dementia
TUESDAY, May 21, 2019 -- Weight gain and weight loss in older adults are both associated with an increased risk for dementia, according to a study published online May 20 in BMJ Open. Susan Park, from the College of Pharmacy and Research Institute...
Dupilumab Cuts Exacerbations in Late-Onset Asthma
TUESDAY, May 21, 2019 -- Dupilumab is associated with significantly reduced severe exacerbation rates in patients with late-onset asthma with or without fixed airway obstruction, according to a study presented at the American Thoracic Society 2019...

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