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Promentis Pharmaceuticals commences phase 2 studies for SXC-2023 targeting Glutamatergic mechanism

Promentis is developing SXC-2023 along with other compounds that engage System xc-, a central nervous system target addressing glutamatergic imbalance and oxidative stress, to treat trichotillomania and other

The post Promentis Pharmaceuticals commences phase 2 studies for SXC-2023 targeting Glutamatergic mechanism appeared first on Pharmaceutical Business review.


Kyn Therapeutics, Celgene partner on immuno-oncology therapies development

The collaboration will combine the immuno-oncology expertise and pipeline of Kyn Therapeutics with the capabilities of Celgene in development and commercialization of drugs in areas of high unmet

The post Kyn Therapeutics, Celgene partner on immuno-oncology therapies development appeared first on Pharmaceutical Business review.


Lilly’s second immune-oncology candidate using Zymeworks’ Azymetric platform to start clinical trials

In accordance with Zymeworks’ 2014 licensing and collaboration agreement with Lilly, Zymeworks will receive a milestone payment of US$8.0 million for Lilly’s submission of an IND application for

The post Lilly’s second immune-oncology candidate using Zymeworks’ Azymetric platform to start clinical trials appeared first on Pharmaceutical Business review.


Vaccinex completes enrollment for SIGNAL Huntington’s disease trial

In June 2015, Vaccinex, the Huntington Study Group (HSG), and the University of Rochester’s Clinical Trials Coordination Center (CTCC) launched SIGNAL, the first clinical trial to investigate a

The post Vaccinex completes enrollment for SIGNAL Huntington’s disease trial appeared first on Pharmaceutical Business review.


ADC doses first patient in phase I trial of ADCT-601 in advanced solid tumors

ADC Therapeutics, an oncology drug discovery and development company that specializes in the development of proprietary antibody drug conjugates (ADCs), today announced that the first patient has been

The post ADC doses first patient in phase I trial of ADCT-601 in advanced solid tumors appeared first on Pharmaceutical Business review.


Acrotech to buy seven hematology/oncology products from Spectrum

Under the deal, Spectrum will secure $160m in an upfront cash payment, while up to $140m in regulatory and sales-based milestones. Spectrum Pharmaceuticals president and CEO Joe Turgeon

The post Acrotech to buy seven hematology/oncology products from Spectrum appeared first on Pharmaceutical Business review.


Janssen gets EC nod for prostate cancer drug Erleada

Erleada is a next generation oral androgen receptor inhibitor approved to treat adult patients with nmCRPC who are at high risk of developing metastatic disease. Apalutamide holds capacity

The post Janssen gets EC nod for prostate cancer drug Erleada appeared first on Pharmaceutical Business review.


Luye Pharma grants AstraZeneca exclusive rights to promote Xuezhikang Capsules in mainland China

This is the first time that a multinational pharmaceutical company has gained exclusive authorization in China to promote an innovative drug independently developed by a Chinese pharmaceutical company.

The post Luye Pharma grants AstraZeneca exclusive rights to promote Xuezhikang Capsules in mainland China appeared first on Pharmaceutical Business review.


Juvenescence closes first tranche of series B financing for further growth and development

Juvenescence intends to complete its $100 million Series B financing with the closing of a second tranche in Q1 2019. Juvenescence has now raised over $110 million in

The post Juvenescence closes first tranche of series B financing for further growth and development appeared first on Pharmaceutical Business review.


Schott to invest €300m in pharmaceutical packaging buisness

Through the investment, Schott plans to expand its primary business of glass tubing, used as the starting material for pharmaceutical packaging, and also pharmaceutical packaging made of glass and

The post Schott to invest €300m in pharmaceutical packaging buisness appeared first on Pharmaceutical Business review.




Drugs.com - News for Health Professionals
Headline news from Drugs.com. Comprehensive and up-to-date drug news for both consumers and healthcare professionals.

Mandibular Contour Surgery Training System Beneficial
FRIDAY, Jan. 18, 2019 -- An intraoral mandibular contour surgery (MCS) training system is effective for improving clinical surgery time and accuracy, according to a study published online Jan. 17 in JAMA Facial Plastic Surgery. Jia Qiao, M.D., from...
Assessing Symptoms After 4 Weeks of Psychotherapy Helpful in Teens
FRIDAY, Jan. 18, 2019 -- Therapists implementing interpersonal psychotherapy for depressed adolescents (IPT-A) should routinely monitor depression symptoms and consider augmenting treatment for insufficient responders as early as week 4 of...
Wait Times Have Improved in VA Health Care System
FRIDAY, Jan. 18, 2019 -- From 2014 to 2017, there were improvements in wait times in the Department of Veterans Affairs (VA) health care system, resulting in reduced wait times versus the private sector (PS) in 2017, according to a study published...
Medication Treatment for Substance Abuse Up in Facilities
FRIDAY, Jan. 18, 2019 -- From 2007 to 2016, there was an increase in the proportion of substance use treatment facilities offering medication treatment (MT), according to a study published in the January issue of Health Affairs. Using data from...
Mindfulness, Stress Linked to Menopausal Symptoms
FRIDAY, Jan. 18, 2019 -- Higher mindfulness and lower stress are independently associated with lower menopausal symptom scores among midlife women, according to a study published online Jan. 17 in Climacteric. Richa Sood, M.D., from the Mayo Clinic...
Frailty Could Increase Susceptibility for Dementia
FRIDAY, Jan. 18, 2019 -- Frailty and Alzheimer disease-related brain changes independently contribute to dementia status, according to a study published in the February issue of The Lancet Neurology. Lindsay M.K. Wallace, from the Nova Scotia Health...
Oral Hepatoselective Glucokinase Activator Promising in T2DM
FRIDAY, Jan. 18, 2019 -- Use of the oral hepatoselective glucokinase activator (GKA) TTP399 for type 2 diabetes does not cause hypoglycemia and has no detrimental effect on plasma lipids or liver enzymes, according to a study published online Jan....
Trained Alert Dogs Can Detect Impending T1DM-Related Events
FRIDAY, Jan. 18, 2019 -- Trained alert dogs can help patients with type 1 diabetes regulate their blood glucose levels, according to a study published online Jan. 15 in PLOS ONE. Nicola J. Rooney, Ph.D., from the University of Bristol in the United...
FDA Panel Has Tie Vote on New Type 1 Diabetes Drug
FRIDAY, Jan. 18, 2019 -- A U.S. Food and Drug Administration advisory panel vote on whether to recommend approval of the first oral medication for type 1 diabetes ended in an 8-8 tie Thursday. Despite that result, the FDA is expected to decide by...
Melanoma Survival Varies Among U.S. States
FRIDAY, Jan. 18, 2019 -- U.S. states with more physicians and a larger percentage of non-Hispanic whites have worse melanoma survival, according to a study published online Jan. 16 in the Journal of the American Academy of Dermatology. Zachary H....
FDA Investigating Paclitaxel-Coated Balloons, Paclitaxel-Eluting Stents
FRIDAY, Jan. 18, 2019 -- The U.S. Food and Drug Administration alerted health care providers on Thursday that the agency is investigating the use of paclitaxel-coated balloons and paclitaxel-eluting stents to treat peripheral arterial disease (PAD)...
Inappropriate Antibiotic Rx Common in Privately Insured
FRIDAY, Jan. 18, 2019 -- Less than half of all outpatient antibiotic prescription fills by privately insured nonelderly adults and children in the United States are appropriate or potentially appropriate, according to a study published online Jan....
Mandated Neonatal Abstinence Reporting Helps Quantify Cases
FRIDAY, Jan. 18, 2019 -- Mandated neonatal abstinence syndrome (NAS) surveillance and reporting allows state health departments to quantify incidence and informs programs and services, according to research published in the Jan. 11 issue of the U.S....
Variation in Revascularization for Asymptomatic SIHD Unexplained
FRIDAY, Jan. 18, 2019 -- For asymptomatic patients with stable ischemic heart disease (SIHD) and coronary artery disease (CAD), there is considerable variation in revascularization practice that is not explained by known factors, according to a...
Radiographic Knee Osteoarthritis Tied to Increased Risk for Death
FRIDAY, Jan. 18, 2019 -- Radiographic knee osteoarthritis (RKOA) is associated with an increased risk for mortality from cardiovascular disease (CVD), diabetes, and renal diseases, but self-reported OA is not, according to a study published in the...
Sex Differences Seen in Pursuit of Interventional Cardiology Career
THURSDAY, Jan. 17, 2019 -- Unique factors dissuade female fellows-in-training from pursuing a career in interventional cardiology (IC), according to a study published online Jan. 16 in JACC: Cardiovascular Interventions. Celina M. Yong, M.D., from...
FDA Approves First Generic Version of Epilepsy Drug Sabril
THURSDAY, Jan. 17, 2019 -- The first generic version of Sabril (vigabatrin) has been approved by the U.S. Food and Drug Administration to prevent complex partial seizures in adults and children aged 10 years and older with epilepsy. "The...
WHO: Vaccine Hesitancy a Major Global Health Threat
THURSDAY, Jan. 17, 2019 -- Vaccine hesitancy is among the top 10 health threats facing the world in 2019, the World Health Organization says. The movement against vaccinations has taken hold in a number of countries, including the United States. The...
FDA Down to 5 Weeks of Funding to Review New Drug Applications
THURSDAY, Jan. 17, 2019 -- Due to the federal government shutdown, the U.S. Food and Drug Administration has only about five weeks of funding left to review new drug applications, according to Commissioner Scott Gottlieb, M.D. To keep reviewing...
Antibiotics Often Inappropriately Prescribed for Bronchiolitis in ED
THURSDAY, Jan. 17, 2019 -- Most children younger than 2 years with bronchiolitis seen in U.S. emergency departments and prescribed antibiotics have no documented bacterial coinfection, according to a study published online Jan. 17 in the Journal of...
Achieving Healthy Diet From Sustainable Food Feasible
THURSDAY, Jan. 17, 2019 -- Achieving a healthy diet from sustainable food systems is feasible but will require considerable shifts toward healthy dietary patterns, according to a report from the EAT-Lancet Commission published online Jan. 16 by The...
Nerve Transfer Promising for Acute Flaccid Myelitis Patients
THURSDAY, Jan. 17, 2019 -- Two patients diagnosed with acute flaccid myelitis and upper-extremity neuropathy who were treated with peripheral nerve transfer continue to demonstrate functional recovery at two years, according to a case series...
High Symptom Burden in Elderly Linked to Adverse Outcomes
THURSDAY, Jan. 17, 2019 -- Community-dwelling older adults frequently have co-occurring symptoms, according to a study published online recently in the Journal of the American Geriatrics Society. Kushang V. Patel, Ph.D., M.P.H., from the University...
Risk for Uninsurance in AMI Patients Reduced With Medicaid Expansion
THURSDAY, Jan. 17, 2019 -- Medicaid expansion was associated with a reduced risk for uninsurance among acute myocardial infarction (AMI) patients, according to a study published online Jan. 16 in JAMA Cardiology. Rishi K. Wadhera, M.D., from Harvard...
Hemochromatosis Mutation Linked to Other Morbidity
THURSDAY, Jan. 17, 2019 -- HFE p.C282Y homozygosity, the most common gene mutation causing hereditary hemochromatosis (type 1), is associated with other morbidity in men and women, according to a study published online Jan. 16 in The BMJ. Luke C....
Prevalence of Knee OA Lower With Menopausal Hormone Therapy
THURSDAY, Jan. 17, 2019 -- For postmenopausal women, the prevalence of knee osteoarthritis is lower with menopausal hormone therapy (MHT) use, according to a study published online Dec. 21 in Menopause. Jae Hyun Jung, M.D., Ph.D., from the Korea...
Asthma Undiagnosed in One in Five Urban Adolescents
THURSDAY, Jan. 17, 2019 -- The prevalence of undiagnosed asthma is 20.2 percent among urban adolescents, according to a study published online Jan. 15 in the Journal of Urban Health. Jean-Marie Bruzzese, Ph.D., from the Columbia University School of...
Temporary Impairment in HRQOL After Teen Sports Concussion
THURSDAY, Jan. 17, 2019 -- Adolescent sports-related concussion (SRC) is associated with temporary impairments in health-related quality of life (HRQOL), according to a study published online Jan. 15 in the Journal of Neurosurgery: Pediatrics. Kelly...
Breast Cancer Patients Do Not Overreact to Genetic Testing
THURSDAY, Jan. 17, 2019 -- Among breast cancer patients, more extensive genetic testing is not associated with increased cancer worry, according to a study recently published in JCO Precision Oncology. Steven J. Katz, M.D., M.P.H., from the...
Ertugliflozin Seems Safe, Effective for Type 2 Diabetes Treatment
THURSDAY, Jan. 17, 2019 -- Ertugliflozin appears safe and effective at improving long-term glycemic control among adults with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin, according to a study published online Jan. 7 in...
FDA Approves First Generic Version of Sabril to Help Treat Seizures in Adults and Pediatric Patients with Epilepsy
January 16, 2019 -- The U.S. Food and Drug Administration approved the first generic version of Sabril (vigabatrin) 500 mg tablets for treating complex partial seizures, also called focal seizures, as an adjunctive therapy (given with another...
Dermatologists' Rx for Antibiotics Dropped From 2008 to 2016
WEDNESDAY, Jan. 16, 2019 -- Dermatologists' use of antibiotics to treat inflammatory skin conditions like acne and rosacea is decreasing, according to a study published online Jan. 16 in JAMA Dermatology. John S. Barbieri, M.D., from the University...
Adoption of Advanced Health IT Capabilities Inconsistent
WEDNESDAY, Jan. 16, 2019 -- Adoption of advanced health information technology (HIT) capabilities is inconsistent across health care systems, with electronic health record (EHR) standardization being the strongest predictor of advanced capabilities,...
Low-Income Women Lack Menstrual Hygiene Supplies
WEDNESDAY, Jan. 16, 2019 -- Many low-income women cannot afford menstrual hygiene supplies, according to a study published online Jan. 8 in Obstetrics & Gynecology. Anne Sebert Kuhlmann, Ph.D., M.P.H., from Saint Louis University, and colleagues...
High Levels of Activity, Motor Ability Linked to Better Cognition
WEDNESDAY, Jan. 16, 2019 -- In older adults, higher levels of total daily activity and better motor abilities are associated with better cognition, according to a study published online Jan. 16 in Neurology. Aron S. Buchman, M.D., from the Rush...
Coronary Artery Calcium May Help Predict CVD in South Asians
WEDNESDAY, Jan. 16, 2019 -- The incidence and progression of coronary artery calcium (CAC) in South Asians may be an important prognostic marker of cardiovascular disease, according to a study published online Jan. 11 in the Journal of the American...
Liver Transplant Survival May Improve With Race Matching
WEDNESDAY, Jan. 16, 2019 -- For African-American patients with hepatocellular carcinoma (HCC) undergoing liver transplantation, donor-recipient race matching is associated with improved survival, according to a study published online Jan. 10 in the...
Suicide Risk Up More Than Fourfold for Cancer Patients
WEDNESDAY, Jan. 16, 2019 -- Cancer patients have an increased suicide risk, which is predominant among men and white patients, according to a study published online Jan. 14 in Nature Communications. Nicholas G. Zaorsky, M.D., from the Penn State...
Replacing Sitting Time With Activity Lowers Mortality Risk
WEDNESDAY, Jan. 16, 2019 -- Replacing prolonged sedentary bouts with physical activity reduces mortality risk, but no benefit is seen for replacement with short sedentary bouts, according to a study recently published in the American Journal of...
Complications Higher Than Expected for Invasive Lung Tests
WEDNESDAY, Jan. 16, 2019 -- The rates of complications after invasive diagnostic procedures for lung abnormalities are higher in the community setting than in clinical trials, according to a study published online Jan. 14 in JAMA Internal...

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